Pair Name | Rosmarinic acid, Anti-MUC1 antibody | ||
Phytochemical Name | Rosmarinic acid (PubChem CID: 5281792 ) | ||
Anticancer drug Name | Anti-MUC1 antibody (PubChem CID: / ) | ||
Structure of Phytochemical |
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Rosmarinic acid, Anti-MUC1 antibody | |||
Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
Biological Phenomena | Induction-->Apoptosis | |||
Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
Down-regulation | Expression | BCL-xL | hsa598 | |
Up-regulation | Expression | CASP3 | hsa836 | |
Up-regulation | Expression | CASP9 | hsa842 | |
Down-regulation | Expression | LGALS3 | hsa3958 | |
Up-regulation | Expression | MUC1 | hsa4582 | |
Up-regulation | Expression | TP53 | hsa7157 | |
In Vitro Model | AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 |
Result | Results of the study indicate that combined action of anti-MUC1 and RA is more effective than monotherapy in relation to examined cancer related factors. Such treatment can be considered as new, promising strategy in gastric cancer therapy. |
No. | Title | Href |
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1 | Anti-cancer effect of combined action of anti-MUC1 and rosmarinic acid in AGS gastric cancer cells. Eur J Pharmacol. 2021 Jul 5;902:174119. doi: 10.1016/j.ejphar.2021.174119. | Click |